setback

Từ điển Oxford Advanced Learner 8th

set·back [setback setbacks] BrE [ˈsetbæk] NAmE [ˈsetbæk] noun
a difficulty or problem that delays or prevents sth, or makes a situation worse
•The team suffered a major setback when their best player was injured.
•The breakdown in talks represents a temporary setback in the peace process.

Example Bank:
•That would represent a huge setback in the fight to change our criminal justice system.
•a further setback for the coal industry
•a serious setback to his chances of re-election
•Don't be put off by any early setbacks.
•The breakdown in talks represents a temporary setback in the peace talks.